Generic Zestoretic is used to treat hypertension (high blood pressure). Hydrochlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention. Lisinopril lowers blood pressure and also relieves symptoms of fluid retention.
Generic Zestril is used for treating high blood pressure alone or with other medicines. It is also used to manage heart failure or improve survival after a heart attack.