Generic Phenergan belongs to a group of drugs called phenothiazines. It works by changing the actions of chemicals in your brain. Promethazine (the active ingredient) also acts as an antihistamine. It blocks the effects of the naturally occurring chemical histamine in your body. Phenergan is used to treat allergy symptoms such as itching, runny nose, sneezing, itchy or watery eyes, hives, and itchy skin rashes. Phenergan also prevents motion sickness, and treats nausea and vomiting or pain after surgery. It is also used as a sedative or sleep aid.
Generic Tofranil is used for treating depression. It is also used in some children to help reduce bedwetting. It works by increasing the activity of certain chemicals in the brain that help elevate mood.